Faculty Recruitment for College of Engineering Bioscience, National Yang Ming Chiao Tung University

Faculty Recruitment for College of Engineering Bioscience, National Yang Ming Chiao Tung University

 

The College of Engineering Bioscience (CEB, former College of Biological Science & Technology) at National Yang Ming Chiao Tung University (NYCU) functions as one entity and is composed of Department of Biological Science and Technology (DBT), Institute of Molecular Medicine and Bioengineering (IMB), as well as Institute of Bioinformatics and Systems Biology (IBS). CEB aims to address the current global challenges and construct a healthy, affordable, and sustainable society through the concepts and approaches of engineering bioscience: linking biotechnology, ICT, and computational biology from the molecular level to study fields such as precision medicine, translational engineering, and sustainable technology. CEB is the pioneer in NYCU at the interface of biology-chemistry, -physics, and -engineering. As such, CEB has numerous outstanding achievements in fields of bioelectronics and biosensing, bioinformatics, biomaterials, tissue engineering, microbial engineering, synthetic biology, structural biology, and neurotechnology.

 

Faculty positions available:

Professor, Associate Professor, and Assistant Professor

 

Application requirements:

Applicant should share a similar vision and goal as CEB and has an outstanding record in cutting edge research and teaching at undergraduate and graduate levels. The candidates we are looking for should have a research expertise in (alphabetic order) bio-big data & AI, bioelectronics and biosensing, biomaterials, cell therapy, computational biology, computational chemistry, metabolomics, microbiome, molecular imaging, organoid and tissue engineering, smart medicine, structural biology, sustainable technology, synthetic biology, or any other related disciplines.

In addition, successful candidates will be required to teach courses in English for the first three years of her or his appointment.

      

Deadline for application:

Application submission process will end on December 5th, 2023.

 

Application package should include:

  • Cover letter
  • Curriculum Vitae
  • Publication list and reprint copies of representative publications
  • Research & Teaching plans
  • Three reference letters sent directly by external referees
  • Estimated laboratory start-up budget and instrumentation needs

 

Applications should be sent to the Dr. Eric Hwang (Director of IMB) and cc. Ms. Sunny Kuo through e-mail. Their contact information is listed below:

 

Dr. Eric Hwang (hwangeric@nycu.edu.tw)

Ms. Sunny Kuo (sunny@nycu.edu.tw)

Phone: (+886)-3-5712121 extension 56937 (Ms. Kuo)

CEB webpage: https://cbt.nycu.edu.tw/

 

國立陽明交通大學工程生物科學院徵聘教師啟事

國立陽明交通大學工程生物科學院徵聘教師啟事

 

  • 工程生物科學院(原生物科技學院,下稱本院)由生物科技學系、分子醫學與生物工程研究所、生物資訊及系統生物研究所組成,本院以工程生物科學(Engineering Bioscience)從分子層次鏈結生物科技、ICT與計算生物,發展精準醫藥、轉譯工程及永續科技等領域,以建立健康、幸福、及永續的未來。本院在陽明交通大學立足於化學、物理、工程等尖端科技與生物科學的界面,以跨領域模式聯通基礎科學與產業應用,在生物電子、生物資訊、生醫材料、組織工程、微生物工程、合成生物、結構生物、與神經科技等領域成果豐碩。

  • 師資需求名額:數名。

  • 應徵職位:教授、副教授、助理教授。

  • 應徵資格:

  • 強烈認同本院發展理念與願景,對卓越研究與教學有熱情之生物科技與工程相關領域人才(包含但不限於生物電子、生醫材料、類器官與組織工程、細胞治療、生物大數據AI、計算生物、計算化學、代謝體學、微生物基因體學、合成生物、分子生醫影像、結構生物、永續科技、智慧醫療)皆歡迎申請。

  • 應徵人需有上述或相關領域博士學位

  • 應徵條件:新進教師前三年需以英語授課

  • 應徵截止日期:應徵資料將於2023/12/05截止收件

  • 應提送資料:(必須提供電子檔資料)

          (1)應徵意願書(Cover Letter)

         (2)個人資料(Curriculum Vitae)

         (3)著作清單及代表性論文抽印本

        (4)研究及教學計畫書

        (5)推薦函三封

        (6)實驗室成立預算與設備需求表

  • 應徵方法:
    將上述資料以e-mail寄送至分子醫學與生物工程研究所黃兆祺所長並副本至郭淑卿小姐,相關聯絡資訊如下:

黃兆祺所長(hwangeric@nycu.edu.tw
郭淑卿小姐(sunny@nycu.edu.tw
Tel:+886-3-5712121轉56937 (郭小姐)
網址:https://cbt.nycu.edu.tw/

Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids

蕭育源教授及朱智瑋教授研究團隊發表研究成果於Nucleic Acids Res

連結網址:https://pubmed.ncbi.nlm.nih.gov/37870446/

Abstract

In various autoimmune diseases, dysfunctional TREX1 (Three prime Repair Exonuclease 1) leads to accumulation of endogenous single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and DNA/RNA hybrids in the cytoplasm and triggers immune activation through the cGAS-STING pathway. Although inhibition of TREX1 could be a useful strategy for cancer immunotherapy, profiling cellular functions in terms of its potential substrates is a key step. Particularly important is the functionality of processing DNA/RNA hybrids and RNA substrates. The exonuclease activity measurements conducted here establish that TREX1 can digest both ssRNA and DNA/RNA hybrids but not dsRNA. The newly solved structures of TREX1-RNA product and TREX1-nucleotide complexes show that 2′-OH does not impose steric hindrance or specific interactions for the recognition of RNA. Through all-atom molecular dynamics simulations, we illustrate that the 2′-OH-mediated intra-chain hydrogen bonding in RNA would affect the binding with TREX1 and thereby reduce the exonuclease activity. This notion of higher conformational rigidity in RNA leading TREX1 to exhibit weaker catalytic cleavage is further validated by the binding affinity measurements with various synthetic DNA-RNA junctions. The results of this work thus provide new insights into the mechanism by which TREX1 processes RNA and DNA/RNA hybrids and contribute to the molecular-level understanding of the complex cellular functions of TREX1 as an exonuclease.

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