113學年度陽明交通大學生物科技學院碩士班甄試入學備取通知

113學年度陽明交通大學生物科技學院碩士班甄試入學備取通知

113學年度碩士班甄試入學備取生名單及報到注意事項
即日起至112年12月11日(一)下午3點前 (不含六、日、國定假日)完成報到手續

一、報到地點:新竹市博愛街75號賢齊館325室。
二、報到登記時需攜帶以下資料:大學成績單正本、畢業證書正本(應屆畢業生請填寫切結書)。
※未報到者視同放棄,缺額將由備取生依序遞補登記報到。
如欲放棄請填寫回覆放棄聲明書或回覆信件告知。

生物科技學系甲組
2010038備1
2010036備2
2010001備3
2010005備4
2010028備5
2010002備6
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2010011備8
2010039備9
2010014備10
2010031備11

生物科技學系乙組
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2020001備4
2020039備5

生物科技學系丁組
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2030007備2

分子醫學與生物工程研究所甲組
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2040007備3
2040004備4

分子醫學與生物工程研究所乙組
2050006備1
2050003備2

Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases

朱智瑋教授研究團隊發表研究成果於Nature Chemistry

連結網址:https://www.nature.com/articles/s41557-023-01361-4

Abstract

Many peptide-derived natural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashion. Each amino acid is coupled to a designated peptidyl carrier protein (PCP) through two distinct reactions catalysed sequentially by the single active site of the adenylation domain (A-domain). Accumulating evidence suggests that large-amplitude structural changes occur in different NRPS states; yet how these molecular machines orchestrate such biochemical sequences has remained elusive. Here, using single-molecule Förster resonance energy transfer, we show that the A-domain of gramicidin S synthetase I adopts structurally extended and functionally obligatory conformations for alternating between adenylation and thioester-formation structures during enzymatic cycles. Complementary biochemical, computational and small-angle X-ray scattering studies reveal interconversion among these three conformations as intrinsic and hierarchical where intra-A-domain organizations propagate to remodel inter-A–PCP didomain configurations during catalysis. The tight kinetic coupling between structural transitions and enzymatic transformations is quantified, and how the gramicidin S synthetase I A-domain utilizes its inherent conformational dynamics to drive directional biosynthesis with a flexibly linked PCP domain is revealed.

Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy

王雲銘教授研究團隊發表研究成果於 Cancer Cell International

連結網址:https://pubmed.ncbi.nlm.nih.gov/38001420/

Abstract

Background: Despite intensive developments of adoptive T cell and NK cell therapies, the efficacy against solid tumors remains elusive. Our study demonstrates that macrophage-based cell therapy could be a potent therapeutic option against solid tumors.

Methods: To this end, we determine the effect of a natural triterpene glycoside, cucumarioside A2-2 (CA2-2), on the polarization of mouse macrophages into the M1 phenotype, and explore the antitumor activity of the polarized macrophage. The polarization of CA2-2-pretreated macrophages was analyzed by flow cytometry and confocal imaging. The anti-cancer activity of CA2-2 macrophages was evaluated against 4T1 breast cancer cells and EAC cells in vitro and syngeneic mouse model in vivo.

Results: Incubation of murine macrophages with CA2-2 led to polarization into the M1 phenotype, and the CA2-2-pretreated macrophages could selectively target and kill various types of cancer in vitro. Notably, loading near-infrared (NIR) fluorochrome-labeled nanoparticles, MnMEIO-mPEG-CyTE777, into macrophages substantiated that M1 macrophages can target and penetrate tumor tissues in vivo efficiently.

Conclusion: In this study, CA2-2-polarized M1 macrophages significantly attenuated tumor growth and prolonged mice survival in the syngeneic mouse models. Therefore, ex vivo CA2-2 activation of mouse macrophages can serve as a useful model for subsequent antitumor cellular immunotherapy developments.

Keywords: Anticancer; Cucumarioside A2-2; Holothurian triterpene glycoside; Immunotherapy; M1 macrophage.

國立陽明交通大學113年度碩博士班甄試入學新生座談會暨備取生報到注意事項

1.只要有備取名額釋放出來,我們會儘速於生科院網頁通知備取公告https://cbt.nycu.edu.tw/,也會寄送E-mail通知您。

2.本院謹訂於112125()上午10:00舉辦新生座談會並開放各實驗室參訪(中午備有餐點),非常歡迎備取生也參與當天座談會,一則可讓備取生提前瞭解可能遞補之機會,再則也可使將來遞補之備取生瞭解各位老師實驗室研究情形。

3.系(所)聯絡方式,電話:03-5729287、傳真:03-5729288

生物科技學院113學年新生座談會

時間:112年12月5日(星期二)

09:30–10:00正取生報到(地點:賢齊館310室)

10:00–10:30師生介紹(地點:賢齊館310室)

10:30–12:00參訪實驗室

12:00–13:00午餐(賢齊館310室)

13:00–16:00  參訪實驗室

碩士班甄試榜單https://sr2.aa.nycu.edu.tw/action.aspx?id=49722893-d200-4f70-8dd4-48280c702761

博士班甄試榜單https://sr2.aa.nycu.edu.tw/action.aspx?id=a48563db-9f4f-49ca-9036-adb06a522259

國立陽明交通大學113年度碩博士班甄試入學新生座談會暨正取生報到注意事項

國立陽明交通大學113年度碩博士班甄試入學新生座談會暨正取生報到注意事項

1.請正取生親自攜身分證正本、歷年成績單、畢業證書正本,請於112年12月5日(星期二)上午九時三十分前,至博愛校區賢齊館310室辦理報到手續,逾時未報到者,以放棄錄取資格論。(報到時須繳驗學歷(力)證件,應屆畢業生尚未領取畢業證書者,可填寫切結書辦理報到。)另在職生須附上在職證明書正本。

2.本院謹訂於112年12月5日(二)上午10:00舉辦新生座談會並開放各實驗室參訪(中午備有餐點),歡迎正、備取生踴躍參加。

生物科技學院113學年新生座談會

時間:112年12月5日(星期二)

09:30–10:00正取生報到(地點:賢齊館310室)

10:00–10:30師生介紹(地點:賢齊館310室)

10:30–12:00參訪實驗室

12:00–13:00午餐(賢齊館310室)

13:00–16:00參訪實驗室

3.錄取系(所)聯絡方式,電話:03-5729287、傳真:03-5729288

4.切結書

5.放棄聲明書

6.二月入學申請書及學位證書切結書

碩士班甄試榜單https://sr2.aa.nycu.edu.tw/action.aspx?id=49722893-d200-4f70-8dd4-48280c702761

博士班甄試榜單https://sr2.aa.nycu.edu.tw/action.aspx?id=a48563db-9f4f-49ca-9036-adb06a522259

Faculty Recruitment for College of Engineering Bioscience, National Yang Ming Chiao Tung University

Faculty Recruitment for College of Engineering Bioscience, National Yang Ming Chiao Tung University

 

The College of Engineering Bioscience (CEB, former College of Biological Science & Technology) at National Yang Ming Chiao Tung University (NYCU) functions as one entity and is composed of Department of Biological Science and Technology (DBT), Institute of Molecular Medicine and Bioengineering (IMB), as well as Institute of Bioinformatics and Systems Biology (IBS). CEB aims to address the current global challenges and construct a healthy, affordable, and sustainable society through the concepts and approaches of engineering bioscience: linking biotechnology, ICT, and computational biology from the molecular level to study fields such as precision medicine, translational engineering, and sustainable technology. CEB is the pioneer in NYCU at the interface of biology-chemistry, -physics, and -engineering. As such, CEB has numerous outstanding achievements in fields of bioelectronics and biosensing, bioinformatics, biomaterials, tissue engineering, microbial engineering, synthetic biology, structural biology, and neurotechnology.

 

Faculty positions available:

Professor, Associate Professor, and Assistant Professor

 

Application requirements:

Applicant should share a similar vision and goal as CEB and has an outstanding record in cutting edge research and teaching at undergraduate and graduate levels. The candidates we are looking for should have a research expertise in (alphabetic order) bio-big data & AI, bioelectronics and biosensing, biomaterials, cell therapy, computational biology, computational chemistry, metabolomics, microbiome, molecular imaging, organoid and tissue engineering, smart medicine, structural biology, sustainable technology, synthetic biology, or any other related disciplines.

In addition, successful candidates will be required to teach courses in English for the first three years of her or his appointment.

      

Deadline for application:

Application submission process will end on December 5th, 2023.

 

Application package should include:

  • Cover letter
  • Curriculum Vitae
  • Publication list and reprint copies of representative publications
  • Research & Teaching plans
  • Three reference letters sent directly by external referees
  • Estimated laboratory start-up budget and instrumentation needs

 

Applications should be sent to the Dr. Eric Hwang (Director of IMB) and cc. Ms. Sunny Kuo through e-mail. Their contact information is listed below:

 

Dr. Eric Hwang (hwangeric@nycu.edu.tw)

Ms. Sunny Kuo (sunny@nycu.edu.tw)

Phone: (+886)-3-5712121 extension 56937 (Ms. Kuo)

CEB webpage: https://cbt.nycu.edu.tw/

 

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