Author Archives: ethanilan

Faculty Recruitment for Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University

  1. The College of Biological Science and Technology at National Yang Ming Chiao Tung University aims to address the current global challenges and construct a healthy, affordable, and sustainable society through the concepts and approaches of Engineering Biological Science. The Institute of bioinformatics and systems biology is the nation’s first Institute of Bioinformatics and recruited outstanding students from the two major fields of biotechnology (biology) and information. The research domains of the Institute included diverse and complex subjects such as genetic bioinformatics, structural bioinformatics, molecular simulation, database structure and design, bioinformatics algorithms, structural biology, molecular and cellular biology, genetics, molecular evolution, and genomics. Our Institute actively collaborates with major hospitals and research institutions to study clinical data and cultivate both theory and application in top bioinformatics and systems biology talents.
  2. Number of faculty positions: 1 position
  3. Faculty positions available: Professor, Associate Professor, and Assistant Professor
  4. Application requirements:
  5. Applicant should share a similar vision and goal as the College of Biological Science and Technology and has an outstanding record in cutting edge research and teaching at undergraduate and graduate levels. He or she should also have a PhD degree in biotechnology, life sciences, bioinformatics, chemistry or biochemistry, physics, chemical engineering, electrical engineering, mechanical engineering, computer sciences, or any other related disciplines. Those with expertise in bioinformatics, computation biology, structural bioinformatics, and related disciplines will be considered with higher priority.
  6. Additional Requirements: Successful candidates will be required to teach courses in English for the first three years of his or her appointment.
  7. Deadline for application: Application review process will begin on April 11, 2022
  8. Application package should include:
    1. 應徵意願書 (Cover Letter)
    2. 個人資料 (Curriculum Vitae)
    3. Publication list and reprint copies of representative publications
    4. Research & Teaching plans
    5. Three reference letters sent directly by external referees
    6. Estimated laboratory start-up budget and instrumentation needs.
  9. Please send the application package to:
    Applications should be sent to the Dr. Ethan Lan and cc. Ms. Meiling Lai through e-mail. Their contact information is listed below:

College of Biological Science and Technology, National Yang Ming Chiao Tung University
Dr. Ethan Lan, Associate Dean (ethanilan@nycu.edu.tw)
Ms. Meiling Lai (meiling@nycu.edu.tw)
Tel:+886-3-5712121 extension: 56983 (Ms. Lai)
CBT hompage:https://cbt.nycu.edu.tw

國立陽明交通大學生物科技學院聘請教師啟事

  1. 針對二十一世紀全人類面臨的各項挑戰,本院願景乃以工程生物科學 (Engineering Biological Science) 建立健康、幸福、及永續的未來。生物科技學院架構是以院為核心之一系三所:生物科技學系(所)、分子醫學與生物工程研究所、生物資訊及系統生物研究所。以此,本院在陽明交大立足於化學、物理、工程等尖端科技與生物科學的界面,以跨領域模式聯通基礎科學與產業應用,在藥物設計、智慧醫療、生物電子、生醫材料、組織工程、微生物工程、合成生物、結構生物、神經工程、與生物資訊等領域成果豐碩。
  2. 師資需求名額:若干名。
  3. Faculty positions available: Professor, Associate Professor, and Assistant Professor
  4. Application requirements:
    1. 強烈認同本院發展理念與願景,對卓越研究與教學有熱情之生物科技相關領域人才(包含但不限於生物科技、生命科學、生物資訊、化學、物理、化工、電機、機械、資工等科系)皆歡迎申請。
    2. 應徵人需有上述或相關領域博士學位
  5. Additional Requirements: Successful candidates will be required to teach courses in English for the first three years of his or her appointment.
  6. 應徵截止日期:應徵資料審查將於2021/08/31開始
  7. Application package should include:
    1. 應徵意願書(Cover Letter)並請註明擬應徵之系所
    2. 個人資料(Curriculum Vitae)
    3. 著作清單及代表性論文抽印本。
    4. 研究及教學計畫書。
    5. 推薦函三封
    6. 實驗室成立預算與設備需求表
  8. Please send the application package to:
    將上述資料以e-mail寄送至生物科技學院蘭宜錚副院長並cc. 郭珍佑小姐,相關聯絡資訊如下:

College of Biological Science and Technology, National Yang Ming Chiao Tung University
Dr. Ethan Lan, Associate Dean (ethanilan@nctu.edu.tw)
郭珍佑小姐(cynthia@mail.nctu.edu.tw)
Tel:+886-3-5712121轉56901 (郭小姐)
CBT hompage:https://cbt.nycu.edu.tw

國立陽明交通大學生物科技學院聘請教師啟事

  1. 針對二十一世紀全人類面臨的各項挑戰,本院願景乃以工程生物科學 (Engineering Biological Science) 建立健康、幸福、及永續的未來。生物科技學院架構是以院為核心之一系三所:生物科技學系(所)、分子醫學與生物工程研究所、生物資訊及系統生物研究所。以此,本院在陽明交大立足於化學、物理、工程等尖端科技與生物科學的界面,以跨領域模式聯通基礎科學與產業應用,在藥物設計、智慧醫療、生物電子、生醫材料、組織工程、微生物工程、合成生物、結構生物、神經工程、與生物資訊等領域成果豐碩。
  2. 師資需求名額:若干名。
  3. Faculty positions available: Professor, Associate Professor, and Assistant Professor
  4. Application requirements:
    1. 強烈認同本院發展理念與願景,對卓越研究與教學有熱情之生物科技相關領域人才(包含但不限於生物科技、生命科學、生物資訊、化學、物理、化工、電機、機械、資工等科系)皆歡迎申請。
    2. 應徵人需有上述或相關領域博士學位
  5. Additional Requirements: Successful candidates will be required to teach courses in English for the first three years of his or her appointment.
  6. 應徵截止日期:應徵資料審查將於2021/08/31開始
  7. Application package should include:
    1. 應徵意願書(Cover Letter)並請註明擬應徵之系所
    2. 個人資料(Curriculum Vitae)
    3. 著作清單及代表性論文抽印本。
    4. 研究及教學計畫書。
    5. 推薦函三封
    6. 實驗室成立預算與設備需求表
  8. Please send the application package to:
    將上述資料以e-mail寄送至生物科技學院蘭宜錚副院長並cc. 郭珍佑小姐,相關聯絡資訊如下:

College of Biological Science and Technology, National Yang Ming Chiao Tung University
Dr. Ethan Lan, Associate Dean (ethanilan@nctu.edu.tw)
郭珍佑小姐(cynthia@mail.nctu.edu.tw)
Tel:+886-3-5712121轉56901 (郭小姐)
CBT hompage:https://cbt.nycu.edu.tw

APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling

蕭育源教授研究團隊發表研究成果於 Nature communications

連結: https://www.nature.com/articles/s41467-020-20853-2

Abstract

The exonuclease activity of Apurinic/apyrimidinic endonuclease 1 (APE1) is responsible for processing matched/mismatched terminus in various DNA repair pathways and for removing nucleoside analogs associated with drug resistance. To fill in the gap of structural basis for exonucleolytic cleavage, we determine the APE1-dsDNA complex structures displaying end-binding. As an exonuclease, APE1 does not show base preference but can distinguish dsDNAs with different structural features. Integration with assaying enzyme activity and binding affinity for a variety of substrates reveals for the first time that both endonucleolytic and exonucleolytic cleavage can be understood by an induced space-filling model. Binding dsDNA induces RM (Arg176 and Met269) bridge that defines a long and narrow product pocket for exquisite machinery of substrate selection. Our study paves the way to comprehend end-processing of dsDNA in the cell and the drug resistance relating to APE1.

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