第1屆傑出院友名單

生物科技學院第1屆傑出院友名單

國立陽明交通大學生物科技學院111學年度第1屆傑出院友當選名單出爐了!今年遴選出的3位傑出院友榮獲此殊榮。

當選的傑出院友將於112年4月8日院慶慶祝大會中公開表揚,並邀請傑出院友傳承其成功之心路歷程,以為後進學子之楷模。

報名連結:https://sites.google.com/view/2023-nycu-cbt-day/%E5%A0%B1%E5%90%8D

傑出院友名單如下:

吳世揚

(88年生科碩畢)

現職:

宣捷幹細胞生技股份有限公司總經理

傑出事蹟

  • 協助推動特管法立案
  • 協助新創生技公司獲得ISO、GMP等相關證照。
  • 在細胞治療上取得授權,並大力推動細胞治療。

 

翁順隆

(104年生科博畢)

現職:

新竹馬偕醫院院長

傑出事蹟

  • 成立竹竹苗首間Covid-19病毒檢測實驗室,榮獲中華民國醫師公會全國聯合會110年防疫特殊貢獻獎
  • 新竹市醫師公會110年度防疫貢獻獎

郭鐘達

(92年生科博畢)

現職:

中華科技大學校長

傑出事蹟

  • 未滿50歲任科技大學校長,彰顯生科院育才卓越
  • 專利獲取及論文發表豐碩,體現生科院教導靈活多元
  • 聘請多位院友至中華科技大學執教,發揚交大「飲水思源」校風
  • 帶領中華科技大學多面向發展,延續交大「求實學、務實業」的教育特色

 

國立陽明交通大學112年度碩士班考試入學新生座談會暨正取生報到注意事項

國立陽明交通大學112年度碩士班考試入學新生座談會暨正取生報到注意事項

1.請正取生親自攜身分證正本、歷年成績單、畢業證書正本,請於112年3月14日(星期二)上午九時三十分前,至博愛校區賢齊館310室辦理報到手續,逾時未報到者,以放棄錄取資格論。(報到時須繳驗學歷(力)證件,應屆畢業生尚未領取畢業證書者,可填寫切結書辦理報到。)另在職生須附上在職證明書正本。

2.本院謹訂於112年3月14日(二)上午10:00舉辦新生座談會並開放各實驗室參訪(中午備有餐點),歡迎正、備取生踴躍參加。

生物科技學院112學年新生座談會

時間:112年3月14日(星期二)

09:30–10:00正取生報到(地點:賢齊館310室)

10:00–10:30師生介紹(地點:賢齊館310室)

10:30–12:00參訪實驗室

12:00–13:00午餐(賢齊館310室)

13:00–16:00參訪實驗室

3.錄取系(所)聯絡方式,電話:03-5729287、傳真:03-5729288

4.切結書

5.放棄聲明書

碩士班考試榜單

Enhanced intrinsic functional connectivity in the visual system of visual artist: Implications for creativity

謝仁俊教授研究團隊發表研究成果於Frontiers in Neuroscience

連結網址:https://www.frontiersin.org/articles/10.3389/fnins.2023.1114771/full

 

Introduction: This study sought to elucidate the cognitive traits of visual artists (VAs) from the perspective of visual creativity and the visual system (i.e., the most fundamental neural correlate).

 

Methods: We examined the local and long-distance intrinsic functional connectivity (FC) of the visual system to unravel changes in brain traits among VAs. Twenty-seven university students majoring in visual arts and 27 non-artist controls were enrolled.

 

Results: VAs presented enhanced local FC in the right superior parietal lobule, right precuneus, left inferior temporal gyrus (ITG), left superior parietal lobule, left angular gyrus, and left middle occipital gyrus. VAs also presented enhanced FC with the ITG that targeted the visual area (occipital gyrus and cuneus), which appears to be associated with visual creativity.

 

Discussion: The visual creativity of VAs was correlated with strength of intrinsic functional connectivity in the visual system. Learning-induced neuroplasticity as a trait change observed in VAs can be attributed to the macroscopic consolidation of consociated neural circuits that are engaged over long-term training in the visual arts and aesthetic experience. The consolidated network can be regarded as virtuoso-specific neural fingerprint.

抵免學分注意事項

各位同學,請注意

  1. 申請抵免學分者,請於112年2月24(五)下班前將申請單及學分證明等相關資料繳交至系辦。
  2. 學生若申請抵免需經指導教授或授課老師同意,方可申請。
  3. 新生請於加退選結束前繳交【生科院選指導教授申請表】,逾期未繳交者將有影響畢業口試之虞。
  4. 新生請於112年2月24(五)下班前盡速至系辦領回您的畢業證書。
    請各位同學務必養成隨時上網查看最新公告,以免喪失自身權益。

Role of the stress-responsive two-component system CpxAR in regulating fimbriae expression in Klebsiella pneumoniae CG43

彭慧玲教授研究團隊發表研究成果於J Microbiol Immunol Infect.

連結網址:https://pubmed.ncbi.nlm.nih.gov/36898943/

Abstract

Background: CpxAR is a two-component system that allows bacteria to reorganize
envelope structures in response to extracellular stimuli. CpxAR negatively affects type 1 fimbriae expression in Klebsiella pneumoniae CG43, a hypervirulent strain. The involvement of CpxAR in the regulation of type 3 fimbriae expression was investigated.
Methods: cpxAR, cpxA, and cpxR gene-specific deletion mutants were generated. The deletion effects on the expression of type 1 and type 3 fimbriae were analyzed via measuring the promoter activity, mannose sensitive yeast agglutination activity, biofilm formation, and the production of the major pilins FimA and MrkA respectively. RNA sequencing analysis of CG43S3, DcpxAR, DcpxR and Dfur was employed to study the regulatory mechanism influencing the expression of type 3 fimbriae.
Results: Deletion of cpxAR increased type 1 and type 3 fimbrial expression. Comparative transcriptomic analysis showed that the expression of oxidative stress-responsive enzymes, type 1 and type 3 fimbriae, and iron acquisition and homeostasis control systems were differentially affected by cpxAR or cpxR deletion. Subsequent analysis revealed that the small RNA RyhB negatively affects the expression of type 3 fimbriae, while CpxAR positively controls ryhB expression. Finally, the site-directed mutation of the predicted interacting sequences of RyhB with the mRNA of MrkA attenuated the RyhB repression of type 3 fimbriae.

A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations

林勇欣副教授研究團隊發表研究成果於PLOS ONE

連結網址:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0281903

Abstract

Here in this study we adopted genome-wide association studies (GWAS) to investigate the genetic components of the personality constructs in the Chinese Personality Assessment Inventory 2 (CPAI-2) in Taiwanese Hakka populations, who are likely the descendants of a recent admixture between a group of Chinese immigrants with high emigration intention and a group of the Taiwanese aboriginal population generally without it. A total of 279 qualified participants were examined and genotyped by an Illumina array with 547,644 SNPs to perform the GWAS. Although our sample size is small and that unavoidably limits our statistical power (Type 2 error but not Type 1 error), we still found three genomic regions showing strong association with Enterprise, Diversity, and Logical vs. Affective Orientation, respectively. Multiple genes around the identified regions were reported to be nervous system related, which suggests that genetic variants underlying the certain personalities should indeed exist in the nearby areas. It is likely that the recent immigration and admixture history of the Taiwanese Hakka people created strong linkage disequilibrium between the emigration intention-related genetic variants and their neighboring genetic markers, so that we could identify them despite with only limited statistical power.

A lesion‑selective albumin‑CTLA4Ig as a safe and effective treatment for collagen‑induced arthritis

鄒協成副教授研究團隊發表研究成果於 Inflammation and Regeneration

連結網址:https://pubmed.ncbi.nlm.nih.gov/36797799/

Abstract

Background: CTLA4Ig is a dimeric fusion protein of the extracellular domain of cytotoxic T-lymphocyte protein 4 (CTLA4) and an Fc (Ig) fragment of human IgG1 that is approved for treating rheumatoid arthritis. However, CTLA4Ig may induce adverse effects. Developing a lesion-selective variant of CTLA4Ig may improve safety while maintaining the efficacy of the treatment.

Methods: We linked albumin to the N-terminus of CTLA4Ig (termed Alb-CTLA4Ig) via a substrate sequence of matrix metalloproteinase (MMP). The binding activities and the biological activities of Alb-CTLA4Ig before and after MMP digestion were analyzed by a cell-based ELISA and an in vitro Jurkat T cell activation assay. The efficacy and safety of Alb-CTLA4Ig in treating joint inflammation were tested in mouse collagen-induced arthritis.

Results: Alb-CTLA4Ig is stable and inactive under physiological conditions but can be fully activated by MMPs. The binding activity of nondigested Alb-CTLA4Ig was at least 10,000-fold weaker than that of MMP-digested Alb-CTLA4Ig. Nondigested Alb-CTLA4Ig was unable to inhibit Jurkat T cell activation, whereas MMP-digested Alb-CTLA4Ig was as potent as conventional CTLA4Ig in inhibiting the T cells. Alb-CTLA4Ig was converted to CTLA4Ig in the inflamed joints to treat mouse collagen-induced arthritis, showing similar efficacy to that of conventional CTLA4Ig. In contrast to conventional CTLA4Ig, Alb-CTLA4Ig did not inhibit the antimicrobial responses in the spleens of the treated mice.

Conclusions: Our study indicates that Alb-CTLA4Ig can be activated by MMPs to suppress tissue inflammation in situ. Thus, Alb-CTLA4Ig is a safe and effective treatment for collagen-induced arthritis in mice.

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