Monthly Archives: 7 月 2022

Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth

林奇宏教授研究團隊發表研究成果於 Nature communications

連結:https://www.nature.com/articles/s41467-022-31825-z

Abstract Regulation of fatty acid uptake, lipid production and storage, and metabolism of lipid droplets (LDs), is closely related to lipid homeostasis, adipocyte hypertrophy and obesity. We report here that stomatin, a major constituent of lipid raft, participates in adipogenesis and adipocyte maturation by modulating related signaling pathways. In adipocyte-like cells, increased stomatin promotes LD growth or enlargements by facilitating LD-LD fusion. It also promotes fatty acid uptake from extracellular environment by recruiting effector molecules, such as FAT/CD36 translocase, to lipid rafts to promote internalization of fatty acids. Stomatin transgenic mice fed with high-fat diet exhibit obesity, insulin resistance and hepatic impairments; however, such phenotypes are not seen in transgenic animals fed with regular diet. Inhibitions of stomatin by gene knockdown or OB-1 inhibit adipogenic differentiation and LD growth through downregulation of PPARγ pathway. Effects of stomatin on PPARγ involves ERK signaling; however, an alternate pathway may also exist.

111 年度生科司業務說明暨座談會

111 年度生科司業務說明暨座談會

111 年度生科司業務說明暨座談會

 

一、   時間:111 年 7 月 15 日(星期五)上午 10 時 00 分

 

二、   地點:陽明交通大學交大校區       賢齊館321會議室

三、   主講人:科技部生科司 陳鴻震司長

 

四、   時程規劃:

 

時間

主題

主講人

09:30~10:00

入場

10:00~10:10

開場致詞

楊進木院長

生物科技學院院長

10:10~11:00

生科司業務說明

陳鴻震 司長

科技部生科司

11:00~12:00

綜合座談及討論暨年輕學者座談會

陳鴻震 司長

科技部生科司

 

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